Although COVID-19 and influenza (commonly known as the flu) are caused by different viruses—SARS-CoV-2 and influenza viruses respectively—they share many similarities in how they spread and the symptoms they produce, which often makes it difficult to distinguish between the two without testing. Both are contagious respiratory illnesses that can cause fever, cough, fatigue, sore throat, and body aches, and both can lead to severe complications like pneumonia, hospitalization, or even death, especially in high-risk groups such as the elderly, those with chronic medical conditions, and the immunocompromised¹. However, there are key differences. COVID-19 has been associated with more severe illness in certain populations and has caused more widespread disruption globally due to its rapid transmission and potential for long-term symptoms, often referred to as “long COVID”². Additionally, COVID-19 tends to have a longer incubation period than influenza, meaning symptoms may take longer to appear after exposure³.
Vaccination plays a critical role in reducing the risk of infection and severe illness from both viruses18. Annual flu vaccines are widely available and updated regularly to match the circulating strains. Likewise, COVID-19 vaccines in Malaysia have been updated to target newer variants and are available at Klinik Kesihatan nationwide. Individuals can book appointments via MySejahtera or opt for walk-in vaccinations, as announced by the Ministry of Health Malaysia on 19 June 2025 ⁴. Receiving both vaccines is safe and recommended, particularly before the peak respiratory illness season. This is especially important because it is possible for someone to contract both influenza and COVID-19 at the same time, a condition known as coinfection⁵ ⁹ ¹⁰ ¹¹. Studies have shown that patients with both infections may experience more severe symptoms and worse clinical outcomes, including a higher risk of hospitalization17 and mortality⁶. The immune system is already compromised when fighting one virus, and the presence of a second can further strain the body’s ability to respond effectively16.
Being aware of treatment options is crucial. For influenza, antiviral medications can reduce the severity and duration of symptoms when taken within 4812 hours of onset⁷. COVID-19 treatments have also evolved, with antiviral drugs and monoclonal antibody therapies available for eligible patients, especially those at risk of severe illness⁸. Early testing and diagnosis are important for both diseases, as prompt treatment improves outcomes. Importantly, supportive care—such as rest, hydration, and fever management—remains a key part of home recovery for mild cases13.
Ultimately, staying informed and proactive is your best defence. Vaccination, good hygiene practices like regular handwashing and mask-wearing in crowded places, and prompt medical attention when symptoms arise can help protect not only yourself but also those around you. While COVID-19 and the flu may continue to coexist, our understanding and tools to manage them have grown significantly14. Talk to your healthcare provider about getting vaccinated and what treatment options are available should you become ill15. Protecting your health starts with awareness and action.
References
- Centers for Disease Control and Prevention. Similarities and Differences between Flu and COVID-19. Accessed July 2025. Available from: https://www.cdc.gov/flu/about/flu-vs-covid19.html#:~:text=Compared%20with%20flu%2C%20COVID%2D19,for%20longer%20periods%20of%20time.
- Mayo Clinic. COVID-19 vs. Flu: Similarities and Differences. Accessed July 2025. Available from: https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-vs-flu/art-20490339
- National Institute of Health. Is It Flu, COVID-19, Allergies, or a Cold World Health Organization. Accessed July 2025. Available from: https://newsinhealth.nih.gov/2022/01/it-flu-covid-19-allergies-or-cold
- Ministry of Health Malaysia. Siaran Media KKM 19-06-2025: Status Terkini COVID-19 di Malaysia. Accessed July 2025. Available from: https://covid-19.moh.gov.my/semasa-kkm/2025/06/siaran-media-kkm-19-06-2025-status-terkini-covid-19-di-malaysia
- Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis. 10.1371/journal.pone.0251170.
- The Lancet. Outcomes of influenza and SARS-CoV-2 coinfection in hospitalized patients. Accessed July 2025. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-67362200383-X/fulltext
- National Institutes of Health. Antiviral Drugs for Influenza. Accessed July 2025. Available from: https://www.niaid.nih.gov/diseases-conditions/influenza-treatment
- Emergency Use Authorization for COVID-19 Treatments. Accessed July 2025. Available from:https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization
- BMC Infectious Disease. Co-infection of SARS‐CoV‐2 and influenza A/B among patients with COVID-19: a systematic review and meta-analysis. Accessed July 2025. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-10521-5
- PNAS Nexus. SARS-CoV-2 and influenza coinfection throughout the COVID-19 pandemic. https://academic.oup.com/pnasnexus/article/1/3/pgac071/6628667
- CDC MMWR. Prevalence of SARS-CoV-2 and Influenza Coinfection and Clinical Outcomes. https://www.cdc.gov/mmwr/volumes/71/wr/mm7150a4.htm
- Influenza Antiviral Medications: Summary for Clinicians. https://www.cdc.gov/flu/hcp/antivirals/summary-clinicians.html
- Treating COVID-19 at home: Care tips for you and others Accessed August 2025. Available from: https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/treating-covid-19-at-home/art-20483273
- World Health Organization. Coronavirus disease (COVID-19): How to protect yourself and others. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public
- Centers for Disease Control and Prevention. COVID-19 Treatments and Medications. https://www.cdc.gov/covid/treatment/index.html
- NIH Co-infections as Modulators of Disease Outcome: Minor Players or Major Players? https://pmc.ncbi.nlm.nih.gov/articles/PMC8290219/pdf/fmicb-12-664386.pdf
- COVID-19 and Influenza Coinfection Outcomes among Hospitalized Patients in the United States: A Propensity Matched Analysis of National Inpatient Sample https://pmc.ncbi.nlm.nih.gov/articles/PMC9783554/
- World Health Organization. Vaccines and immunization: What is vaccination? Accessed August 2025. Available from: https://www.who.int/news-room/questions-and-answers/item/vaccines-and-immunization-what-is-vaccination